A Scientific Perspective on Dry Needling – From Physiological Mechanisms to Clinical Outcomes (EBP)

By: Eyal Feigin, Specialist in Manual Therapy, Dry Needling, and Rehabilitation | Giveon Peled, Founder of the STB Method and Pain Management Specialist.

Introduction

In the last decade, Dry Needling has evolved from a "complementary" treatment to a central and indispensable tool in modern physical therapy and orthopedic rehabilitation. Unlike traditional Chinese acupuncture, which is based on the philosophy of energy flow (Qi), Orthopedic Dry Needling is grounded in topographical anatomy, neurophysiology, and rigorous clinical research. This article reviews the scientific mechanisms that allow a simple sterile needle to trigger profound changes in the musculoskeletal system.

 

The Mechanical Mechanism: Local Twitch Response (LTR)

One of the unique characteristics of Dry Needling is the Local Twitch Response (LTR)—an involuntary spinal cord reflex of the muscle fibers in response to the needle stimulus. Research indicates that eliciting an LTR is critical for the successful treatment of myofascial trigger points. At the biomechanical level, the needling creates a "disruption" in the local pain-spasm cycle. This action alters the membrane tension of the muscle fibers, leading to an immediate relaxation of the Taut Band.

 

Biochemical Changes in the Muscle Environment

The pioneering research of Shah et al. (2005, 2008) provided a breakthrough in our understanding of Dry Needling. Using micro-dialysis sampling, researchers discovered high concentrations of pro-inflammatory and pain-sensitizing substances, such as Substance P, CGRP, and inflammatory cytokines, within the trigger point environment. It was demonstrated that following successful needling that produced an LTR, there was a dramatic decrease in the concentration of these substances. This biochemical shift is what facilitates pain reduction and improved tissue function.

 

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Neurological Effects and the Gate Control Mechanism

Dry Needling does not only act at the local muscular level; it activates complex neurological mechanisms within the Central Nervous System (CNS). The mechanical stimulus of the needle activates A-delta nerve fibers, which send rapid signals to the dorsal horn of the spinal cord. These signals "block" the transmission of slower pain signals (C-fibers) according to the Gate Control Theory. Additionally, needling stimulates the release of endogenous opioids (such as endorphins and enkephalins) that contribute to systemic analgesia.

 

Research Evidence and Meta-Analysis

Recent systematic reviews and meta-analyses (e.g., Gattie et al., 2017) support the efficacy of Dry Needling for treating neck and lower back pain in the short and medium term. The literature emphasizes that needling is most effective when integrated into a multimodal treatment plan that includes manual therapy and active exercise.

 

Clinical Insight

As someone who has been teaching and practicing in this field for over a decade, I view anatomical precision as paramount. Without a deep understanding of anatomy, dry needling remains a superficial technique. In our courses at Manual IL, we emphasize the direct link between clinical findings and the precise stimulation of the target tissue.

 

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Summary

Dry Needling is a powerful tool based on hard science. Understanding the physiological mechanisms—from the LTR to biochemical and neurological shifts—enables the clinician to provide treatment that is more precise, safe, and effective.

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